Brian Doctrow, Ph.D. – U.S. National Institutes of Health
At a Glance
- Researchers found that irisin, an exercise-induced hormone, improves cognitive performance in mice.
- The hormone, which is identical in people, could potentially be used to treat cognitive disorders such as Alzheimer’s disease.
Exercise may benefit brain health and improve cognitive performance during aging. It’s also associated with reduced Alzheimer’s disease risk and cognitive decline. But the mechanisms responsible aren’t well understood. Factors secreted into the bloodstream may play a role. If so, these factors would be promising leads for developing treatments for cognitive disorders.
The study was supported in part by several NIH institutes (see below). Results appeared in Nature Metabolism on August 20, 2021.
First, the researchers deleted the gene encoding FNDC5 in mice, thereby removing irisin. They then compared the effects of exercise on cognitive performance in these “knockout” mice and in control mice. Some mice had an exercise wheel to run on, while others did not.
Control mice who could freely exercise showed improved cognitive performance over those that could not. But in the knockout mice, exercise made no difference in cognitive performance. The knockout mice also showed greater cognitive decline with age than control mice.
Next, the researchers delivered irisin directly into the mice’s brains. Doing so improved cognitive performance in both knockout and control mice.
The team examined the neurons in the knockout mice in a part of the hippocampus. They found that newly born neurons in this area had abnormal activation patterns, structure, and gene activity.
The researchers then tested the therapeutic potential of irisin in mouse models of Alzheimer’s disease. They delivered the gene for irisin into the mice, which led to irisin production in the liver. The blood of these mice, in turn, contained elevated irisin levels. Two months after treatment, the researchers tested the mice’s cognitive performance. The irisin-treated mice performed better on the tests than untreated mice. Treated mice also showed signs of reduced neuroinflammation—a process related to neurodegenerative diseases—in the hippocampus. In addition, the researchers found that irisin could cross the blood-brain barrier to act on the brain.
These results suggest that exercise may improve cognitive performance by increasing irisin levels. “This is particularly important inasmuch as irisin, a small natural peptide, would be much easier to develop into a therapeutic than the much larger membrane-bound protein FNDC5,” Wrann says.
Irisin is identical in mice and people. Its blood levels in people have also been shown to rise with endurance exercise. It could thus potentially help to treat a variety of cognitive disorders. Wrann adds, “since irisin does not specifically target amyloid plaques, but rather neuroinflammation directly, we’re optimistic it could have beneficial effects on neurodegenerative diseases beyond just Alzheimer’s.”
—by Brian Doctrow, Ph.D.
Learn More at NIH
- Exercise-Induced Protein May Reverse Age-Related Cognitive Decline
- Exercise and New Nerve Cell Growth in Alzheimer’s Disease
- Shivering Triggers Brown Fat to Produce Heat and Burn Calories
- Moderate Exercise May Improve Memory in Older Adults
- A Well-Aged Mind: Maintaining Your Cognitive Health
- Dealing with Dementia: When Thinking and Behavior Decline
- Exercise and Physical Activity
- Alzheimer’s Disease & Related Dementias
References: Exercise hormone irisin is a critical regulator of cognitive function. Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD. Nat Metab. 2021 Aug;3(8):1058-1070. doi: 10.1038/s42255-021-00438-z. Epub 2021 Aug 20. PMID: 34417591
Funding: NIH’s National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Cure Alzheimer’s Fund; Alzheimer’s Association; Massachusetts General Hospital’s McCance Center for Brain Health, Claflin Distinguished Scholar Award, and Molecular Imaging Core; Harvard NeuroDiscovery Center; Hassenfeld Child Health Innovation Institute; Harvard Brain Science Initiative; Michael Smith Foundation for Health Research (MSFHR); FRAXA Research Foundation; Fragile X Research Foundation of Canada (FXRFC); Natural Sciences and Engineering Research Council of Canada (NSERC); Canadian Institutes of Health Research (CIHR); The JPB Foundation
This article was originally published on NIH.Gov, you can read the original article here.